Blocking angiotensin pathway induces anti-fibrotic effects in a mouse model of schistosomiasis by decreasing egg burden and granulomatous reaction

Background: Schistosoma mansoni infection is associated with hepatic fibrosis and portal hypertension. Previous studies reported that blocking some components of rennin angiotensin system can ameliorate the liver pathology induced by S. mansoni infection. Aim: The present study investigated potential effect losartan, an II receptor antagonist, enalapril, angiotensin-converting enzyme inhibitor, on caused mansoni in a murine model. Materials Methods: S. mansoni-infected mice were treated at week 5 after infection or their combination. A group infected was reference drug praziquantel (PZQ) as controls. Parasitological histological parameters investigated. Results: Our results showed when compared treatment losartan alone considerable decrease in index (28.92% versus 25.09%), spleen (47.19% 37.08%), worm burden (38.7% 24.8%), tissue egg load (62.7% 54%), granuloma size (40.4% 29.4%) (48.7% 29.4%). combination enalapril did not produce more pronounced than those losartan. Conclusion: Our suggest promising amelioration but further to determine effects other antischistosomal agents such are recommended.